Gene copy number changes in dermatofibrosarcoma protuberans - a fine-resolution study using array comparative genomic hybridization.
Cytogenet Genome Res
; 115(3-4): 283-8, 2006.
Article
in En
| MEDLINE
| ID: mdl-17124411
ABSTRACT
Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing, low-grade dermal tumor. Cytogenetic and FISH studies have revealed that the chromosomal rearrangements characteristic of DFSP tumors involve both translocations and the formation of a supernumerary ring derived from chromosomes 17 and 22. The t(17;22) (q22;q13.1) translocation generates a gene fusion between COL1A1 and PDGFB, which serves as a diagnostic marker of DFSP. In the present study we performed array-CGH (aCGH) analysis on ten DFSP tumors. The COL1A1 region at 17q was gained in 71% (5/7) of the samples and the PDGFB region at 22q was gained in 43% (3/7) of the individual samples. In addition to the 17q and 22q gains, altogether 17 minimal common regions of gain and one region of loss were detected.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skin Neoplasms
/
Dermatofibrosarcoma
/
Computational Biology
/
Nucleic Acid Hybridization
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Cytogenet Genome Res
Journal subject:
GENETICA
Year:
2006
Type:
Article
Affiliation country:
Finland