Anticoagulants/pharmacology; Blood Platelets/drug effects; Fibrinolytic Agents/pharmacology; Lipoproteins/pharmacology; Platelet Aggregation Inhibitors/pharmacology; Receptors, Proteinase-Activated/antagonists & inhibitors; Animals; Anticoagulants/metabolism; Anticoagulants/therapeutic use; Blood Platelets/metabolism; Carotid Artery, Common/surgery; Cell Membrane/metabolism; Cell Membrane Permeability; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinolytic Agents/metabolism; Fibrinolytic Agents/therapeutic use; Flow Cytometry; Fluorescence Resonance Energy Transfer; Humans; In Vitro Techniques; Lipoproteins/metabolism; Lipoproteins/therapeutic use; Male; Mice; Microscopy, Video; Platelet Aggregation/drug effects; Platelet Aggregation Inhibitors/metabolism; Platelet Aggregation Inhibitors/therapeutic use; Receptor, PAR-1/antagonists & inhibitors; Receptors, Proteinase-Activated/metabolism; Receptors, Thrombin/antagonists & inhibitors; Thrombin/metabolism; Thromboplastin/metabolism; Thrombosis/blood; Thrombosis/metabolism; Thrombosis/prevention & control; Time Factors