Active antiviral T-lymphocyte response can be redirected against tumor cells by antitumor antibody x MHC/viral peptide conjugates.

Cesson, Valérie; Stirnemann, Kathrin; Robert, Bruno; Luescher, Immanuel; Filleron, Thomas; Corradin, Giampietro; Mach, Jean-Pierre; Donda, Alena

Cesson, Valérie; Stirnemann, Kathrin; Robert, Bruno; Luescher, Immanuel; Filleron, Thomas; Corradin, Giampietro; Mach, Jean-Pierre; Donda, Alena.

Affiliation

Cesson V; Department of Biochemistry, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.

Clin Cancer Res ; 12(24): 7422-30, 2006 Dec 15.

Article in En | MEDLINE | ID: mdl-17189415

Subject(s)

Antibodies, Neoplasm/immunology; Antigens, Viral/immunology; Immunoconjugates/immunology; Major Histocompatibility Complex/immunology; T-Lymphocytes, Cytotoxic/immunology; Animals; Antigens, Surface/immunology; Antigens, Surface/metabolism; Antigens, Viral/chemistry; Carcinoembryonic Antigen/chemistry; Carcinoembryonic Antigen/immunology; Carcinoma/immunology; Carcinoma/metabolism; Carcinoma/therapy; Colonic Neoplasms/immunology; Colonic Neoplasms/metabolism; Colonic Neoplasms/therapy; Glycoproteins/immunology; H-2 Antigens/immunology; Histocompatibility Antigen H-2D; Immunization/methods; Immunoconjugates/chemistry; Immunoconjugates/therapeutic use; Immunoglobulin Fab Fragments/biosynthesis; Immunoglobulin Fab Fragments/therapeutic use; Immunotherapy/methods; Influenza A virus/immunology; Lymphocytic choriomeningitis virus/immunology; Melanoma, Experimental/immunology; Melanoma, Experimental/metabolism; Melanoma, Experimental/therapy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptide Fragments/immunology; Receptor, ErbB-2/immunology; Viral Core Proteins/immunology; Viral Proteins/immunology; Xenograft Model Antitumor Assays/methods

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Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Cytotoxic / Immunoconjugates / Major Histocompatibility Complex / Antibodies, Neoplasm / Antigens, Viral Type of study: Evaluation_studies Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2006 Type: Article Affiliation country: Switzerland

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