Triterpenoids from Hippophae rhamnoides L. and their nitric oxide production-inhibitory and DPPH radical-scavenging activities.
Chem Pharm Bull (Tokyo)
; 55(1): 15-8, 2007 Jan.
Article
in En
| MEDLINE
| ID: mdl-17202693
ABSTRACT
In our investigation on the chemical constituents of Hippophae rhamnoides L., the chloroform-soluble fraction of the 80% acetone extract of branch bark was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide and recombinant mouse interferon-gamma-activated murine macrophage-like cell line, RAW 264.7 cells. Two new triterpenoids, 2-O-trans-p-coumaroyl maslinic acid (1) and 2-O-caffeoyl maslinic acid (2), and three known triterpenoids, oleanolic acid (3), 3-O-trans-p-coumaroyl oleanolic acid (4), and 3-O-caffeoyl oleanolic acid (5), and 6-methoxy-2H-1-benzopyran (6) and beta-sitosterol (7) were isolated from the branch bark extract. Their inhibitory activities on the production of NO in RAW 264.7 cells and radical-scavenging activities were examined.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Triterpenes
/
Biphenyl Compounds
/
Free Radical Scavengers
/
Hippophae
/
Hydrazines
/
Nitric Oxide
Limits:
Animals
Language:
En
Journal:
Chem Pharm Bull (Tokyo)
Year:
2007
Type:
Article