Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants.

Crozatier, C; Farley, S; Mansuy, I M; Dumas, S; Giros, B; Tzavara, E T

Crozatier, C; Farley, S; Mansuy, I M; Dumas, S; Giros, B; Tzavara, E T.

Affiliation

Crozatier C; INSERM U-513, 8 rue de Général Sarrail, 94000 Créteil, France.

Neuroscience ; 144(4): 1470-6, 2007 Feb 23.

Article in En | MEDLINE | ID: mdl-17207580

Subject(s)

Antidepressive Agents/pharmacology; Calcineurin/metabolism; Depressive Disorder/drug therapy; Depressive Disorder/enzymology; Hippocampus/drug effects; Hippocampus/enzymology; Animals; Antidepressive Agents, Tricyclic/pharmacology; Brain-Derived Neurotrophic Factor/drug effects; Brain-Derived Neurotrophic Factor/metabolism; Calcineurin/genetics; Depressive Disorder/physiopathology; Desipramine/pharmacology; Female; Fluoxetine/pharmacology; Hippocampus/physiopathology; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphorylation/drug effects; Receptors, AMPA/drug effects; Receptors, AMPA/metabolism; Selective Serotonin Reuptake Inhibitors/pharmacology; Up-Regulation/drug effects; Up-Regulation/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Calcineurin / Depressive Disorder / Hippocampus / Antidepressive Agents Limits: Animals Language: En Journal: Neuroscience Year: 2007 Type: Article Affiliation country: France

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