Interleukin-12 promotes gamma interferon-dependent neutrophil recruitment in the lung and improves protection against respiratory Streptococcus pneumoniae infection.

Sun, Keer; Salmon, Sharon L; Lotz, Steven A; Metzger, Dennis W

Sun, Keer; Salmon, Sharon L; Lotz, Steven A; Metzger, Dennis W.

Affiliation

Sun K; Center for Immunology and Microbial Disease, MC-151, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA.

Infect Immun ; 75(3): 1196-202, 2007 Mar.

Article in En | MEDLINE | ID: mdl-17210665

Subject(s)

Interferon-gamma/physiology; Interleukin-12/physiology; Lung/metabolism; Neutrophil Infiltration/immunology; Neutrophils/immunology; Neutrophils/pathology; Pneumonia, Pneumococcal/metabolism; Streptococcus pneumoniae/immunology; Animals; Interferon-gamma/deficiency; Interferon-gamma/genetics; Lung/immunology; Lung/microbiology; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophils/microbiology; Pneumonia, Pneumococcal/immunology; Pneumonia, Pneumococcal/prevention & control

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia, Pneumococcal / Streptococcus pneumoniae / Interferon-gamma / Interleukin-12 / Neutrophil Infiltration / Lung / Neutrophils Limits: Animals Language: En Journal: Infect Immun Year: 2007 Type: Article Affiliation country: United States

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