Manipulation of cell cycle progression can counteract the apparent loss of correction frequency following oligonucleotide-directed gene repair.

Engstrom, Julia U; Kmiec, Eric B

Engstrom, Julia U; Kmiec, Eric B.

Affiliation

Engstrom JU; Department of Biological Sciences, University of Delaware, Delaware Biotechnology Institute, 15 Innovation Way, Newark, DE 19711, USA. juliaeng@udel.edu <juliaeng@udel.edu>

BMC Mol Biol ; 8: 9, 2007 Feb 06.

Article in En | MEDLINE | ID: mdl-17284323

Subject(s)

Cell Cycle; Cell Division/genetics; DNA Repair/genetics; Genetic Therapy/methods; Oligonucleotides/therapeutic use; Cell Division/drug effects; Cells, Cultured; Cellular Senescence/drug effects; DNA Repair/drug effects; DNA Replication/drug effects; Humans; Thymidine/pharmacology; Time Factors

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Oligonucleotides / Genetic Therapy / Cell Cycle / Cell Division / DNA Repair Type of study: Guideline Limits: Humans Language: En Journal: BMC Mol Biol Journal subject: BIOLOGIA MOLECULAR Year: 2007 Type: Article

Fulltext

XML

PubMed Links

Search on Google