Integrin alpha1beta1 controls reactive oxygen species synthesis by negatively regulating epidermal growth factor receptor-mediated Rac activation.

Chen, Xiwu; Abair, Tristin D; Ibanez, Maria R; Su, Yan; Frey, Mark R; Dise, Rebecca S; Polk, D Brent; Singh, Amar B; Harris, Raymond C; Zent, Roy; Pozzi, Ambra

Chen, Xiwu; Abair, Tristin D; Ibanez, Maria R; Su, Yan; Frey, Mark R; Dise, Rebecca S; Polk, D Brent; Singh, Amar B; Harris, Raymond C; Zent, Roy; Pozzi, Ambra.

Affiliation

Chen X; Department of Medicine, Division of Nephrology, Vanderbilt University, Nashville, TN 37232, USA.

Mol Cell Biol ; 27(9): 3313-26, 2007 May.

Article in En | MEDLINE | ID: mdl-17339338

Subject(s)

ErbB Receptors/metabolism; Integrin alpha1beta1/metabolism; Reactive Oxygen Species/metabolism; rac GTP-Binding Proteins/metabolism; Animals; Cell Membrane/metabolism; Cell Shape; Cells, Cultured; Collagen/biosynthesis; Down-Regulation; Enzyme Activation; Humans; Integrin alpha1beta1/deficiency; Integrin alpha1beta1/genetics; Ligands; Mesangial Cells/cytology; Mesangial Cells/metabolism; Mice; Mice, Knockout; Phosphorylation; Protein Binding; Proto-Oncogene Proteins c-vav/metabolism; Receptors, Collagen/metabolism; rac GTP-Binding Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Reactive Oxygen Species / Rac GTP-Binding Proteins / Integrin alpha1beta1 / ErbB Receptors Limits: Animals / Humans Language: En Journal: Mol Cell Biol Year: 2007 Type: Article Affiliation country: United States

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