ClC-3 expression enhances etoposide resistance by increasing acidification of the late endocytic compartment.

Weylandt, Karsten H; Nebrig, Maxim; Jansen-Rosseck, Nils; Amey, Joanna S; Carmena, David; Wiedenmann, Bertram; Higgins, Christopher F; Sardini, Alessandro

Weylandt, Karsten H; Nebrig, Maxim; Jansen-Rosseck, Nils; Amey, Joanna S; Carmena, David; Wiedenmann, Bertram; Higgins, Christopher F; Sardini, Alessandro.

Affiliation

Weylandt KH; Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, United Kingdom.

Mol Cancer Ther ; 6(3): 979-86, 2007 Mar.

Article in En | MEDLINE | ID: mdl-17363491

Subject(s)

Antineoplastic Agents/pharmacology; Chloride Channels/metabolism; Drug Resistance, Neoplasm; Endosomes/drug effects; Etoposide/pharmacology; Neuroectodermal Tumors/metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Acridine Orange; Cell Proliferation/drug effects; Cells, Cultured/drug effects; Drug Resistance, Multiple; Endosomes/metabolism; Genes, MDR/physiology; Humans; Immunoenzyme Techniques; Kidney/drug effects; Muscle Proteins/pharmacology; Neuroectodermal Tumors/drug therapy; Neuroectodermal Tumors/pathology

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Collection: 01-internacional Database: MEDLINE Main subject: Endosomes / Neuroectodermal Tumors / Chloride Channels / Drug Resistance, Neoplasm / Etoposide / Antineoplastic Agents Limits: Humans Language: En Journal: Mol Cancer Ther Journal subject: ANTINEOPLASICOS Year: 2007 Type: Article Affiliation country: United kingdom

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