Sprouty-2 regulates oncogenic K-ras in lung development and tumorigenesis.

Shaw, Alice T; Meissner, Alexander; Dowdle, James A; Crowley, Denise; Magendantz, Margaret; Ouyang, Chensi; Parisi, Tiziana; Rajagopal, Jayaraj; Blank, Leah J; Bronson, Roderick T; Stone, James R; Tuveson, David A; Jaenisch, Rudolf; Jacks, Tyler

Shaw, Alice T; Meissner, Alexander; Dowdle, James A; Crowley, Denise; Magendantz, Margaret; Ouyang, Chensi; Parisi, Tiziana; Rajagopal, Jayaraj; Blank, Leah J; Bronson, Roderick T; Stone, James R; Tuveson, David A; Jaenisch, Rudolf; Jacks, Tyler.

Affiliation

Shaw AT; Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston 02114, USA.

Genes Dev ; 21(6): 694-707, 2007 Mar 15.

Article in En | MEDLINE | ID: mdl-17369402

Subject(s)

Genes, ras; Lung Neoplasms/genetics; Lung Neoplasms/metabolism; Lung/embryology; Membrane Proteins/metabolism; Adaptor Proteins, Signal Transducing; Animals; Base Sequence; Embryo Loss/genetics; Female; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Germ-Line Mutation; Humans; Intracellular Signaling Peptides and Proteins; Lung/abnormalities; Lung/metabolism; Lung/pathology; Lung Neoplasms/pathology; MAP Kinase Signaling System; Membrane Proteins/deficiency; Membrane Proteins/genetics; Mice; Mice, Knockout; Mice, Transgenic; Pregnancy; Protein Serine-Threonine Kinases; RNA/genetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genes, ras / Lung / Lung Neoplasms / Membrane Proteins Limits: Animals / Female / Humans / Pregnancy Language: En Journal: Genes Dev Journal subject: BIOLOGIA MOLECULAR Year: 2007 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google