Synthesis and evaluation of a (99m)Tc-MAMA-propyl-thymidine complex as a potential probe for in vivo visualization of tumor cell proliferation with SPECT.

Celen, Sofie; de Groot, Tjibbe; Balzarini, Jan; Vunckx, Kathleen; Terwinghe, Christelle; Vermaelen, Peter; Van Berckelaer, Lizette; Vanbilloen, Hubert; Nuyts, Johan; Mortelmans, Luc; Verbruggen, Alfons; Bormans, Guy

Celen, Sofie; de Groot, Tjibbe; Balzarini, Jan; Vunckx, Kathleen; Terwinghe, Christelle; Vermaelen, Peter; Van Berckelaer, Lizette; Vanbilloen, Hubert; Nuyts, Johan; Mortelmans, Luc; Verbruggen, Alfons; Bormans, Guy.

Affiliation

Celen S; Laboratory for Radiopharmacy, K.U. Leuven, B-3000 Leuven, Belgium.

Nucl Med Biol ; 34(3): 283-91, 2007 Apr.

Article in En | MEDLINE | ID: mdl-17383578

Subject(s)

Fibrosarcoma/diagnostic imaging; Fibrosarcoma/metabolism; Organotechnetium Compounds/pharmacokinetics; Tomography, Emission-Computed, Single-Photon/methods; Animals; Cell Proliferation; Drug Evaluation, Preclinical/methods; Feasibility Studies; Metabolic Clearance Rate; Mice; Mice, Nude; Molecular Probe Techniques; Neoplasm Staging; Organ Specificity; Organotechnetium Compounds/chemistry; Radiopharmaceuticals/chemical synthesis; Radiopharmaceuticals/pharmacokinetics; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Organotechnetium Compounds / Tomography, Emission-Computed, Single-Photon / Fibrosarcoma Type of study: Evaluation_studies Limits: Animals Language: En Journal: Nucl Med Biol Journal subject: BIOLOGIA / MEDICINA NUCLEAR Year: 2007 Type: Article Affiliation country: Belgium

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