Potent and selective agonists of human melanocortin receptor 5: cyclic analogues of alpha-melanocyte-stimulating hormone.

Bednarek, Maria A; MacNeil, Tanya; Tang, Rui; Fong, Tung M; Cabello, M Angeles; Maroto, Marta; Teran, Ana

Bednarek, Maria A; MacNeil, Tanya; Tang, Rui; Fong, Tung M; Cabello, M Angeles; Maroto, Marta; Teran, Ana.

Affiliation

Bednarek MA; Department of Medicinal Chemistry and Metabolic Disorders, Merck Research Laboratories, Rahway, New Jersey 07065, USA. maria_bednarek@merck.com

J Med Chem ; 50(10): 2520-6, 2007 May 17.

Article in En | MEDLINE | ID: mdl-17455928

Subject(s)

Peptides, Cyclic/chemical synthesis; Receptors, Corticotropin/agonists; alpha-MSH/analogs & derivatives; alpha-MSH/chemical synthesis; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP/biosynthesis; Humans; Melanocyte-Stimulating Hormones/chemical synthesis; Melanocyte-Stimulating Hormones/chemistry; Melanocyte-Stimulating Hormones/pharmacology; Peptides, Cyclic/pharmacology; Radioligand Assay; Receptors, Melanocortin; Structure-Activity Relationship; alpha-MSH/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Peptides, Cyclic / Alpha-MSH / Receptors, Corticotropin Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: United States

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