[Activation of astrocytes effects changes of substance P in cornu dorsal medullae spinalis in chronic prostatitis rats].
Zhonghua Nan Ke Xue
; 13(4): 342-4, 2007 Apr.
Article
in Zh
| MEDLINE
| ID: mdl-17491270
ABSTRACT
OBJECTIVE:
To explore the changes of substance P in cornu dorsal medullae spinalis effected by activation of astrocytes in rats with pain from chronic prostatitis.METHODS:
Sixty SD rats were randomized into three groups the control group (n=20), the chronic prostatitis pain model group (n=20) and the interference group (n=20). The model was induced by injection of complete Freund adjuvant and 3% carrageenan into the prostate. Propentofylline was given with PE-10 in the spinal cord of the rat models. The activation of astrocytes and the distribution of substance P in the spinal cord were detected with immunofluorescence and the changes of substance P observed by radioimmunoassay.RESULTS:
The activation of astrocytes was significantly increased in the models compared with controls, but significantly reduced in interfered group in comparison with the pain model group (P < 0.01), and such was the case with substance P (P <0.01).CONCLUSION:
The activation of astrocytes was one important reason for the changes of substance P excreted from cornu dorsal medullae spinalis in the chronic prostatitis rats.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostatitis
/
Spinal Cord
/
Substance P
/
Astrocytes
Limits:
Animals
Language:
Zh
Journal:
Zhonghua Nan Ke Xue
Journal subject:
MEDICINA REPRODUTIVA
Year:
2007
Type:
Article
Affiliation country:
China