The antibody-mediated targeted delivery of interleukin-15 and GM-CSF to the tumor neovasculature inhibits tumor growth and metastasis.

Kaspar, Manuela; Trachsel, Eveline; Neri, Dario

Kaspar, Manuela; Trachsel, Eveline; Neri, Dario.

Affiliation

Kaspar M; Department of Chemistry and Applied Biosciences, Swiss Federal Institute of Technology, Zurich, Switzerland.

Cancer Res ; 67(10): 4940-8, 2007 May 15.

Article in En | MEDLINE | ID: mdl-17510424

Subject(s)

Adenocarcinoma/therapy; Colonic Neoplasms/therapy; Granulocyte-Macrophage Colony-Stimulating Factor/administration & dosage; Immunoconjugates/pharmacology; Interleukin-15/administration & dosage; Teratocarcinoma/therapy; Adenocarcinoma/blood supply; Adenocarcinoma/immunology; Animals; Cell Growth Processes/drug effects; Cell Growth Processes/immunology; Cloning, Molecular; Colonic Neoplasms/blood supply; Colonic Neoplasms/immunology; Female; Granulocyte-Macrophage Colony-Stimulating Factor/genetics; Granulocyte-Macrophage Colony-Stimulating Factor/pharmacokinetics; Immunoconjugates/genetics; Immunoconjugates/immunology; Immunoconjugates/pharmacokinetics; Immunoglobulin Fragments/genetics; Immunoglobulin Fragments/immunology; Interleukin-15/genetics; Interleukin-15/pharmacokinetics; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Neovascularization, Pathologic/immunology; Neovascularization, Pathologic/therapy; T-Lymphocytes/immunology; Teratocarcinoma/blood supply; Teratocarcinoma/immunology; Tissue Distribution

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Collection: 01-internacional Database: MEDLINE Main subject: Adenocarcinoma / Granulocyte-Macrophage Colony-Stimulating Factor / Teratocarcinoma / Colonic Neoplasms / Immunoconjugates / Interleukin-15 Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cancer Res Year: 2007 Type: Article Affiliation country: Switzerland

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