PKD, PKD2, and p38 MAPK mediate Hsp27 serine-82 phosphorylation induced by neurotensin in pancreatic cancer PANC-1 cells.

Yuan, Jingzhen; Rozengurt, Enrique

Yuan, Jingzhen; Rozengurt, Enrique.

Affiliation

Yuan J; Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine; CURE: Digestive Diseases Research Center and Molecular Biology Institute, University of California, Los Angeles, California 90095, USA.

J Cell Biochem ; 103(2): 648-62, 2008 Feb 01.

Article in En | MEDLINE | ID: mdl-17570131

Subject(s)

Carcinoma, Pancreatic Ductal/pathology; Heat-Shock Proteins/metabolism; Neoplasm Proteins/physiology; Neurotensin/pharmacology; Pancreatic Neoplasms/pathology; Protein Kinase C/physiology; Protein Kinases/physiology; Protein Processing, Post-Translational/drug effects; p38 Mitogen-Activated Protein Kinases/physiology; Anisomycin/pharmacology; Carcinoma, Pancreatic Ductal/metabolism; Cell Line, Tumor/drug effects; Cell Line, Tumor/metabolism; Humans; MAP Kinase Signaling System/drug effects; Pancreatic Neoplasms/metabolism; Phorbol 12,13-Dibutyrate/pharmacology; Phosphorylation/drug effects; Phosphoserine/metabolism; Protein Kinase C/antagonists & inhibitors; Protein Kinase C/genetics; Protein Kinase D2; Protein Kinase Inhibitors/pharmacology; Protein Kinases/genetics; Protein Processing, Post-Translational/physiology; RNA Interference; RNA, Small Interfering/pharmacology; Recombinant Fusion Proteins/metabolism; Signal Transduction/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Pancreatic Neoplasms / Protein Kinases / Protein Kinase C / Neurotensin / Protein Processing, Post-Translational / Carcinoma, Pancreatic Ductal / P38 Mitogen-Activated Protein Kinases / Heat-Shock Proteins / Neoplasm Proteins Limits: Humans Language: En Journal: J Cell Biochem Year: 2008 Type: Article Affiliation country: United States

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