No association between the DAT1 10-repeat allele and ADHD in the Iranian population.
Am J Med Genet B Neuropsychiatr Genet
; 147B(1): 110-1, 2008 Jan 05.
Article
in En
| MEDLINE
| ID: mdl-17582621
ABSTRACT
Association studies between attention-deficit hyperactivity disorder (ADHD) and the 10-repeat allele of a polymorphism (a 40 bp variable number of tandem repeats) in the dopamine transporter gene (DAT1) have resulted in mixed findings in different populations. We performed a case/control study to clarify the contribution of this allele with ADHD in the Iranian population. No association was observed between the 10-allele and disease (chi(2) = 0.081, P < 0.9). Furthermore, no significant difference was observed in the homozygosity of this allele between the case and control groups (chi(2) = 0.022, P < 0.9). Implication of the dopamine transporter gene in the pathophysiology of ADHD warrants investigation of other functional polymorphisms within this gene in the Iranian ADHD patients.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Attention Deficit Disorder with Hyperactivity
/
Alleles
/
Dopamine Plasma Membrane Transport Proteins
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Am J Med Genet B Neuropsychiatr Genet
Journal subject:
GENETICA MEDICA
/
NEUROLOGIA
/
PSIQUIATRIA
Year:
2008
Type:
Article
Affiliation country:
Iran