Use of plasma proteins as solubilizing agents in in vitro permeability experiments: correction for unbound drug concentration using the reciprocal permeability approach.

Katneni, Kasiram; Charman, Susan A; Porter, Christopher J H

Katneni, Kasiram; Charman, Susan A; Porter, Christopher J H.

Affiliation

Katneni K; Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, Melbourne, Victoria 3052, Australia.

J Pharm Sci ; 97(1): 209-24, 2008 Jan.

Article in En | MEDLINE | ID: mdl-17585392

Subject(s)

Blood Proteins/chemistry; Pharmaceutical Preparations/chemistry; Albumins/chemistry; Algorithms; Animals; Carrier Proteins/drug effects; Carrier Proteins/metabolism; Diazepam/chemistry; Digoxin/chemistry; Excipients; In Vitro Techniques; Male; Orosomucoid/chemistry; Permeability; Propranolol/chemistry; Rats; Rats, Sprague-Dawley; Solubility; Surface-Active Agents; Thermodynamics

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Collection: 01-internacional Database: MEDLINE Main subject: Pharmaceutical Preparations / Blood Proteins Limits: Animals Language: En Journal: J Pharm Sci Year: 2008 Type: Article Affiliation country: Australia

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