Lepidepyrone, a new gamma-pyrone derivative, from Neolentinus lepideus, inhibits hyaluronidase.

Hosoe, Tomoo; Sakai, Hideo; Ichikawa, Makoto; Itabashi, Takeshi; Ishizaki, Takayuki; Kawai, Ken-Ichi

Hosoe, Tomoo; Sakai, Hideo; Ichikawa, Makoto; Itabashi, Takeshi; Ishizaki, Takayuki; Kawai, Ken-Ichi.

Affiliation

Hosoe T; Faculty of Pharmaceutical Sciences, Hoshi University, Ebara, Tokyo, Japan. kawai@hoshi.ac.jp

J Antibiot (Tokyo) ; 60(6): 388-90, 2007 Jun.

Article in En | MEDLINE | ID: mdl-17617697

ABSTRACT

In the course of screening for hyaluronidase (HAase) inhibitory agents, a new gamma-pyrone derivative, lepidepyrone, C(8)H(10)O(5), was isolated from the cultured mycelium of the mushroom Neolentinus lepideus TMC-1102 as a major HAase inhibitory compound (IC(50) 3.3 mM). The structure of lepidepyrone was established on the basis of spectroscopic investigation.

Subject(s)

Basidiomycota/chemistry; Enzyme Inhibitors/isolation & purification; Hyaluronoglucosaminidase/antagonists & inhibitors; Pyrones/isolation & purification; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/metabolism; Enzyme Inhibitors/pharmacology; Hyaluronoglucosaminidase/metabolism; Inhibitory Concentration 50; Mass Spectrometry; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Pyrones/chemistry; Pyrones/metabolism; Pyrones/pharmacology; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet

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Collection: 01-internacional Database: MEDLINE Main subject: Pyrones / Basidiomycota / Enzyme Inhibitors / Hyaluronoglucosaminidase Language: En Journal: J Antibiot (Tokyo) Year: 2007 Type: Article Affiliation country: Japan

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