SC-46275: a potent, long-acting gastric antisecretory prostaglandin with low oral bioavailability in the dog.
J Pharmacol Exp Ther
; 259(3): 1004-7, 1991 Dec.
Article
in En
| MEDLINE
| ID: mdl-1762057
ABSTRACT
The synthetic prostaglandin, SC-46275, an omega chain cyclopentenyl analog of enisoprost, was studied to determine its gastric antisecretory potency and duration of action in meal-stimulated innervated (Pavlov) pouch dogs and its p.o. bioavailability in unoperated fasted dogs. SC-46275 exhibited potent antisecretory activity when administered directly into the gastric pouch, the ED50 being 0.01 micrograms/kg. It had a long duration of antisecretory action; significant (P less than or equal to .05) inhibition of total acid output was observed 16 hr after intrapouch administration of 0.03 micrograms/kg. At this dose p.o., neither SC-46275 nor its free acid metabolite was detected in plasma. These data indicate that SC-46275 has novel properties it is a potent, long-acting gastric antisecretory agent which is not readily available systemically after p.o. administration. Thus, potential systemic side effects are expected to be absent or minimized at doses of SC-46275 which inhibit gastric acid secretion, and therefore it might be useful in peptic ulcer disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Alprostadil
/
Gastric Mucosa
/
Anti-Ulcer Agents
Limits:
Animals
Language:
En
Journal:
J Pharmacol Exp Ther
Year:
1991
Type:
Article