Angiotensin-converting enzyme gene polymorphism in Kuwaiti patients with systemic lupus erythematosus.
Clin Exp Rheumatol
; 25(3): 437-42, 2007.
Article
in En
| MEDLINE
| ID: mdl-17631741
ABSTRACT
OBJECTIVE:
To investigate the frequency of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism genotypes in patients with systemic lupus erythematosus (SLE), and to study the correlation between I/D polymorphism of the ACE gene and the clinical manifestations of SLE, especially vascular involvement, lupus nephritis and disease severity.METHODS:
The frequency of ACE gene I/D polymorphism genotypes was determined in 92 patients with SLE from Kuwait, and compared to that in 100 ethnically matched healthy controls using the polymerase chain reaction.RESULTS:
The distribution of ACE I/D polymorphism and allele frequencies in SLE patients was not significantly different from controls. Further analyses of SLE patients showed that there was a significant association between DD genotype and Raynaud's phenomenon (p=0.008, odd ratio=5.4, 95% confidence interval 1.6-18.6). However, there was no significant association between the ACE genotype and lupus nephritis or disease severity.CONCLUSION:
No difference was found between the distribution of the ACE genotype in SLE patients and the general pop-ulation in Kuwait. However, the presence of the DD genotype may confer susceptibility to the development of vascular morbidity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Polymorphism, Genetic
/
Peptidyl-Dipeptidase A
/
Lupus Erythematosus, Systemic
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Clin Exp Rheumatol
Year:
2007
Type:
Article
Affiliation country:
Kuwait