Fatal lactic acidosis and hypoglycemia in a patient with relapsed natural killer/T-cell lymphoma.
Adv Ther
; 24(3): 505-9, 2007.
Article
in En
| MEDLINE
| ID: mdl-17660158
ABSTRACT
Presented here is the first reported case of natural killer (NK)/T-cell lymphoma associated with lactic acidosis (LA) and hypoglycemia. LA and hypoglycemia are rare complications of non-Hodgkin's lymphoma. A 28-year-old male patient with NK/T-cell lymphoma had a relapse after 14 mo of initial remission and was admitted to the hospital because of altered mental status. He developed severe LA (pH, 7.17; lactate, 11.2 mmol/L) and hypoglycemia (42 mg/dL) that was resistant to sodium bicarbonate and glucose infusions. A very brief partial remission was achieved after a cycle of vincristine, dexamethasone, and L-asparaginase was given, but the disease recurred quickly after chemotherapy was discontinued and the patient did not respond to additional chemotherapy. The patient expired at 47 d after relapse. An extensive review of the literature reveals that only 2 of 28 patients have achieved complete remission, and more than 75% of patients died within 1 mo. Furthermore, 90% of previously reported cases had liver involvement. The case described here indicates that non-Hodgkin's lymphoma-induced LA portends a poor prognosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Acidosis, Lactic
/
Killer Cells, Natural
/
Nose Neoplasms
/
Lymphoma, T-Cell
/
Hypoglycemia
Type of study:
Prognostic_studies
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Adv Ther
Journal subject:
TERAPEUTICA
Year:
2007
Type:
Article
Affiliation country:
China