Spherical crystallization: direct spherical agglomeration of salicylic Acid crystals during crystallization.
Science
; 216(4550): 1127-8, 1982 Jun 04.
Article
in En
| MEDLINE
| ID: mdl-17808500
ABSTRACT
Direct spherical agglomeration of salicylic acid crystals during crystallization is described. The needle-like salicylic acid crystals simultaneously form and agglomerate in a mixture of three partially miscible liquids, such as water, ethanol, and chloroform, with agitation. The agglomerates can be made directly into tablets because of their excellent flowability. Spherical crystallization could eliminate the usual separate agglomeration step after crystallization and may be adaptable to other pharmaceutical and chemical systems.
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Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Science
Year:
1982
Type:
Article