Human protein-protein interaction networks and the value for drug discovery.
Drug Discov Today
; 12(17-18): 709-16, 2007 Sep.
Article
in En
| MEDLINE
| ID: mdl-17826683
ABSTRACT
Systematic genome-wide and pathway-specific protein-protein interaction screens have generated a putative, organizing framework of the spatial interconnectivity of a large number of human proteins, including numerous therapeutically relevant disease-associated proteins. The intrinsic value for drug discovery is that these physical protein-protein interaction networks may contribute to a mechanistic understanding of the pathophysiology of disease and can aid in the identification and prioritization of tractable targets and generate hypotheses on how to best drug non-tractable, disease-associated targets. Here, we review the 'therapeutic potential' of the 1st generation sub-genome-scale human interaction networks and disease-associated protein networks generated by yeast two-hybrid screens and affinity purification-mass spectrometry approaches.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Drug Design
/
Proteins
/
Protein Interaction Mapping
Limits:
Humans
Language:
En
Journal:
Drug Discov Today
Journal subject:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Year:
2007
Type:
Article
Affiliation country:
Germany