Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses.

Menetski, J; Mistry, S; Lu, M; Mudgett, J S; Ransohoff, R M; Demartino, J A; Macintyre, D E; Abbadie, C

Menetski, J; Mistry, S; Lu, M; Mudgett, J S; Ransohoff, R M; Demartino, J A; Macintyre, D E; Abbadie, C.

Affiliation

Menetski J; Department of Immunology and Rheumatology, Merck Research Laboratories, P.O. Box 2000, Rahway, NJ 07065, USA.

Neuroscience ; 149(3): 706-14, 2007 Nov 09.

Article in En | MEDLINE | ID: mdl-17870246

Subject(s)

Astrocytes/physiology; Chemokine CCL2/biosynthesis; Chemokine CCL2/physiology; Pain/physiopathology; Animals; Astrocytes/metabolism; Chemokines/biosynthesis; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Freund's Adjuvant; Ganglia, Spinal/metabolism; Hot Temperature; Inflammation/chemically induced; Inflammation/complications; Inflammation/physiopathology; Male; Mice; Pain Measurement; Peripheral Nerve Injuries; Peripheral Nervous System Diseases/complications; Peripheral Nervous System Diseases/physiopathology; Phenotype; Physical Stimulation; Reaction Time/physiology; Reverse Transcriptase Polymerase Chain Reaction; Schwann Cells/physiology; Spinal Cord/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Pain / Astrocytes / Chemokine CCL2 Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neuroscience Year: 2007 Type: Article Affiliation country: United States

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