Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: consequences in receptor affinity and functionality.

Stern, Eric; Muccioli, Giulio G; Bosier, Barbara; Hamtiaux, Laurie; Millet, Régis; Poupaert, Jacques H; Hénichart, Jean-Pierre; Depreux, Patrick; Goossens, Jean-François; Lambert, Didier M

Stern, Eric; Muccioli, Giulio G; Bosier, Barbara; Hamtiaux, Laurie; Millet, Régis; Poupaert, Jacques H; Hénichart, Jean-Pierre; Depreux, Patrick; Goossens, Jean-François; Lambert, Didier M.

Affiliation

Stern E; Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, EA 2692, Lille, France.

J Med Chem ; 50(22): 5471-84, 2007 Nov 01.

Article in En | MEDLINE | ID: mdl-17915849

Subject(s)

Amides/chemical synthesis; Quinolines/chemical synthesis; Receptor, Cannabinoid, CB2/agonists; Receptor, Cannabinoid, CB2/antagonists & inhibitors; Amides/chemistry; Amides/pharmacology; Animals; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Inverse Agonism; Humans; Ligands; Quinolines/chemistry; Quinolines/pharmacology; Radioligand Assay; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Receptor, Cannabinoid, CB2 / Amides Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Type: Article Affiliation country: France

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