Bovine TLR2 and TLR4 properly transduce signals from Staphylococcus aureus and E. coli, but S. aureus fails to both activate NF-kappaB in mammary epithelial cells and to quickly induce TNFalpha and interleukin-8 (CXCL8) expression in the udder.

Yang, Wei; Zerbe, Holm; Petzl, Wolfram; Brunner, Ronald Marco; Günther, Juliane; Draing, Christian; von Aulock, Sonja; Schuberth, Hans-Joachim; Seyfert, Hans-Martin

Yang, Wei; Zerbe, Holm; Petzl, Wolfram; Brunner, Ronald Marco; Günther, Juliane; Draing, Christian; von Aulock, Sonja; Schuberth, Hans-Joachim; Seyfert, Hans-Martin.

Affiliation

Yang W; Research Institute for the Biology of Farm Animals (FBN), Wilhelm-Stahl-Allee 2, 18196 Dummerstorf, Germany.

Mol Immunol ; 45(5): 1385-97, 2008 Mar.

Article in En | MEDLINE | ID: mdl-17936907

Subject(s)

Escherichia coli/immunology; Interleukin-8/immunology; Mammary Glands, Animal/microbiology; NF-kappa B/immunology; Signal Transduction/immunology; Staphylococcus aureus/pathogenicity; Toll-Like Receptor 2/immunology; Toll-Like Receptor 4/immunology; Tumor Necrosis Factor-alpha/immunology; Animals; Animals, Domestic; Cattle; Epithelial Cells; Escherichia coli Infections/veterinary; Immunity; Mammary Glands, Animal/immunology; Staphylococcal Infections/veterinary; Staphylococcus aureus/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: Staphylococcus aureus / Signal Transduction / Interleukin-8 / NF-kappa B / Tumor Necrosis Factor-alpha / Escherichia coli / Toll-Like Receptor 2 / Toll-Like Receptor 4 / Mammary Glands, Animal Limits: Animals Language: En Journal: Mol Immunol Year: 2008 Type: Article Affiliation country: Germany

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