Different prognostic roles of mutations in the helical and kinase domains of the PIK3CA gene in breast carcinomas.

Barbareschi, Mattia; Buttitta, Fiamma; Felicioni, Lara; Cotrupi, Sabrina; Barassi, Fabio; Del Grammastro, Maela; Ferro, Antonella; Dalla Palma, Paolo; Galligioni, Enzo; Marchetti, Antonio

Barbareschi, Mattia; Buttitta, Fiamma; Felicioni, Lara; Cotrupi, Sabrina; Barassi, Fabio; Del Grammastro, Maela; Ferro, Antonella; Dalla Palma, Paolo; Galligioni, Enzo; Marchetti, Antonio.

Affiliation

Barbareschi M; Unit of Surgical Pathology, Laboratory of Molecular Pathology S. Chiara Hospital, Trento, Italy, and Clinical Research Center, Center of Excellence on Aging, University-Foundation, Chieti, Italy.

Clin Cancer Res ; 13(20): 6064-9, 2007 Oct 15.

Article in En | MEDLINE | ID: mdl-17947469

Subject(s)

Breast Neoplasms/metabolism; Carcinoma/metabolism; Gene Expression Regulation, Neoplastic; Mutation; Phosphatidylinositol 3-Kinases/biosynthesis; Phosphatidylinositol 3-Kinases/genetics; Adolescent; Adult; Aged; Aged, 80 and over; Breast Neoplasms/diagnosis; Breast Neoplasms/genetics; Carcinoma/diagnosis; Carcinoma/genetics; Class I Phosphatidylinositol 3-Kinases; Exons; Female; Humans; Middle Aged; Multivariate Analysis; Polymorphism, Single-Stranded Conformational; Prognosis; Protein Structure, Tertiary; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Carcinoma / Gene Expression Regulation, Neoplastic / Phosphatidylinositol 3-Kinases / Mutation Type of study: Diagnostic_studies / Prognostic_studies Limits: Adolescent / Adult / Aged / Aged80 / Female / Humans / Middle aged Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2007 Type: Article Affiliation country: Italy

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