[Efficacy and safety evaluation of glucosamine hydrochloride in the treatment of osteoarthritis].
Zhonghua Wai Ke Za Zhi
; 45(14): 998-1001, 2007 Jul 15.
Article
in Zh
| MEDLINE
| ID: mdl-17961392
ABSTRACT
OBJECTIVE:
To evaluate the efficacy and safety of glucosamine hydrochloride for the treatment of osteoarthritis.METHODS:
A multi-central, randomized, controlled clinical trial of glucosamine hydrochloride comparing glucosamine sulfate for the treatment of osteoarthritis was performed. One hundred and forty-three patients suffering from knee or hip osteoarthritis were randomized into study (glucosamine hydrochloride) or control (glucosamine sulfate) group. Patients in study group orally took glucosamine hydrochloride 2 times daily for 6 weeks, each time 1 capsule, and those in control group took glucosamine sulfate 3 times daily for 6 weeks also, each time 2 capsules.RESULTS:
The symptomatic improvement of joint pain at walking, at rest and stiffness after 6 week treatment with glucosamine hydrochloride was better than those with glucosamine sulfate. The results had significant difference (P < 0.05). Total effective rates of patients with glucosamine hydrochloride was 75.4% and 60.6% with glucosamine sulfate, but no statistical difference. The results suggested both glucosamine had the considerable efficacy in the treatment of osteoarthritis. Three cases in study group and 2 in control group reported mild adverse events. No severe adverse events (SAE) was observed.CONCLUSION:
Glucosamine hydrochloride is as effective and safe as glucosamine sulfate for the treatment of osteoarthritis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Osteoarthritis, Hip
/
Osteoarthritis, Knee
/
Glucosamine
Type of study:
Clinical_trials
Limits:
Female
/
Humans
/
Male
Language:
Zh
Journal:
Zhonghua Wai Ke Za Zhi
Year:
2007
Type:
Article
Affiliation country:
China