Ketorolac tromethamine LS 0.4% versus nepafenac 0.1% in patients having cataract surgery. Prospective randomized double-masked clinical trial.
J Cataract Refract Surg
; 33(11): 1925-9, 2007 Nov.
Article
in En
| MEDLINE
| ID: mdl-17964399
ABSTRACT
PURPOSE:
To compare the clinical, subjective, and objective outcomes of the use of 2 topical nonsteroidal antiinflammatory drugs--ketorolac tromethamine LS 0.4% (Acular) and nepafenac 0.1% (Nevanac)--in patients having cataract surgery.SETTING:
Single-center private practice, Las Vegas, Nevada, USA.METHODS:
One hundred eighty-three patients (193 eyes) with visually significant cataract were recruited for the study. Consenting patients were randomized to a standard regimen of Acular, gatifloxacin 0.3% (Zymar), and prednisolone acetate 1% (Pred Forte) (ketorolac group) or Nevanac, moxifloxacin hydrochloride 0.5% (Vigamox), and prednisolone acetate (Econopred) (nepafenac group). Analysis included subjective complaints (burning, itching, foreign-body sensation, pain level after surgery) and objective findings (visual function, degree of inflammation in the anterior segment, complications).RESULTS:
The ketorolac group consisted of 94 patients (100 eyes) and the nepafenac group, 89 patients (93 eyes). The between-group differences in visual outcomes and anterior chamber inflammation were not statistically significant (mean P = .33). There was a higher incidence of posterior capsule opacification in the nepafenac group (P = 0.019). Patient satisfaction, patient compliance, and postoperative pain control were statistically significantly better in the ketorolac group (P = .022, P = .023, and P = .025, respectively).CONCLUSION:
Ketorolac tromethamine was statistically significantly better than nepafenac in terms of patient satisfaction, compliance, and postoperative pain control.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pain, Postoperative
/
Phenylacetates
/
Uveitis, Anterior
/
Anti-Inflammatory Agents, Non-Steroidal
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Phacoemulsification
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Lens Implantation, Intraocular
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Ketorolac Tromethamine
/
Benzeneacetamides
Type of study:
Clinical_trials
/
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Aged
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Aged80
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Female
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Humans
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Male
/
Middle aged
Language:
En
Journal:
J Cataract Refract Surg
Journal subject:
OFTALMOLOGIA
Year:
2007
Type:
Article
Affiliation country:
United States