Synthesis of an artificial antigen that corresponds to a disaccharide repeating unit of the capsular polysaccharide of Haemophilus influenzae type d. A facile synthesis of methyl 2-acetamido-2-deoxy-beta-D-mannopyranoside.
Carbohydr Res
; 216: 187-96, 1991 Sep 02.
Article
in En
| MEDLINE
| ID: mdl-1797379
ABSTRACT
The synthesis is described of p-nitrophenyl 2-acetamido-3-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta -D- mannopyranosiduronic acid, corresponding to the disaccharide repeating unit of the capsular polysaccharide of Haemophilus influenzae type d, which, after conversion of the p-nitro- into a p-amino-phenyl residue, may be attached to a protein to make an artificial antigen for immunological studies. The synthesis incorporates a facile route to the 2-acetamido-2-deoxy-beta-D-mannopyranosyl unit.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Disaccharides
/
Methylmannosides
/
Antigens, Bacterial
Language:
En
Journal:
Carbohydr Res
Year:
1991
Type:
Article
Affiliation country:
Sweden