The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1.

Ordureau, Alban; Smith, Hilary; Windheim, Mark; Peggie, Mark; Carrick, Emma; Morrice, Nick; Cohen, Philip

Ordureau, Alban; Smith, Hilary; Windheim, Mark; Peggie, Mark; Carrick, Emma; Morrice, Nick; Cohen, Philip.

Affiliation

Ordureau A; MRC Protein Phosphorylation Unit, The Sir James Black Centre, College of Life Sciences, University of Dundee, Dow Street, Dundee DD15 5EH, Scotland, UK.

Biochem J ; 409(1): 43-52, 2008 Jan 01.

Article in En | MEDLINE | ID: mdl-17997719

Subject(s)

Interleukin-1 Receptor-Associated Kinases/chemistry; Interleukin-1 Receptor-Associated Kinases/metabolism; Catalysis; Cell Line; Enzyme Activation; Humans; I-kappa B Kinase/metabolism; Inflammation; Interleukin-1/metabolism; NF-kappa B p50 Subunit/metabolism; Phosphorylation; Protein Isoforms; Transfection; Ubiquitination

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Interleukin-1 Receptor-Associated Kinases Limits: Humans Language: En Journal: Biochem J Year: 2008 Type: Article Affiliation country: United kingdom

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