Effect of a laser irradiation on the vascularisation of safety and X-ray radiated bone.
Annu Int Conf IEEE Eng Med Biol Soc
; 2007: 5846-9, 2007.
Article
in En
| MEDLINE
| ID: mdl-18003343
ABSTRACT
Thermal preconditioning induces a cytoprotective effect and promotes tissue recovering. Laser is an appropriated method to generate a controlled and reproducible heating. Bone healing, a crucial challenge in medicine, is affected by X-ray radiation which induces a chronic antiangiogenic effect. So, this study aims to investigate the role of laser preconditioning on the vascularisation of bone after X-ray radiation. An optical bone chamber allowed the study of the vascularization process. The vascular density (VD) was determined using image processing. A longitudinal study was performed on 20 rabbits divided in four groups #1 control group (n=5); #2 laser irradiation alone (diode laser 810nm, fluence= 48J/cm2) (n=5). #3 X-ray radiation (18.75Gy) alone (n=5), #4 laser preconditioning 24 hours before a X-ray radiation (n=5). VD remained stable during 12-week follow up for groups #1 and #2. X-ray radiation lead to an important decrease of the superficial bone vascularization in group #3. The decrease of the vascularization was limited in group #4 highlighting a different evolution between group #3 and #4. Those results were confirmed by histological analysis. Our preliminary findings show that laser preconditioning preserves vascularization in X-ray radiated bone site, outlining a novel approach for the bone healing in which the vascular supply has been injured.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Skull
/
X-Rays
/
Neovascularization, Physiologic
/
Lasers
Type of study:
Observational_studies
Limits:
Animals
Language:
En
Journal:
Annu Int Conf IEEE Eng Med Biol Soc
Year:
2007
Type:
Article
Affiliation country:
France