Differential inhibition of rat and human hepatic cytochrome P450 by Andrographis paniculata extract and andrographolide.

Pekthong, D; Martin, H; Abadie, C; Bonet, A; Heyd, B; Mantion, G; Richert, L

Pekthong, D; Martin, H; Abadie, C; Bonet, A; Heyd, B; Mantion, G; Richert, L.

Affiliation

Pekthong D; Laboratoire de Toxicologie Cellulaire, EA 3921 Optimisation Métabolique et Cellulaire, UFR des Sciences Médicales et Pharmaceutiques, Besançon, France.

J Ethnopharmacol ; 115(3): 432-40, 2008 Feb 12.

Article in En | MEDLINE | ID: mdl-18053665

Subject(s)

Andrographis/chemistry; Cytochrome P-450 Enzyme System/drug effects; Diterpenes/pharmacology; Enzyme Inhibitors/pharmacology; Adult; Aged; Animals; Aryl Hydrocarbon Hydroxylases/drug effects; Aryl Hydrocarbon Hydroxylases/metabolism; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP3A/drug effects; Cytochrome P-450 CYP3A/metabolism; Cytochrome P-450 Enzyme System/metabolism; Diterpenes/administration & dosage; Diterpenes/isolation & purification; Drug Interactions; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/isolation & purification; Female; Humans; Inhibitory Concentration 50; Male; Microsomes, Liver/enzymology; Middle Aged; Rats; Rats, Wistar; Species Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Cytochrome P-450 Enzyme System / Andrographis / Diterpenes / Enzyme Inhibitors Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged Language: En Journal: J Ethnopharmacol Year: 2008 Type: Article Affiliation country: France

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