[Subleukemic acute monophagocytic leukemia. A biological phenotype close to malignant histiocytosis]. / Leucemia aguda monofagocítica subleucémica. Un fenotipo biológico próximo a la histiocitosis maligna.
Sangre (Barc)
; 36(5): 427-30, 1991 Oct.
Article
in Es
| MEDLINE
| ID: mdl-1816640
ABSTRACT
An 80 year-old woman presented subleukaemic acute monoblastic leukaemia (AML-M5a). Her bone marrow showed invasion by highly dysplastic histio-monocytic cells of great size and wide cytoplasm, with intense phagocytic activity (erythrophagocytosis was frequently seen), and with abnormal karyotype (50XX, +8, +8, +16, +21). The different malignant and reactive features of the mononuclear phagocytic system are commented, along with the haemophagocytic activity of the histio-monocytic cells in different states. The cytogenetic anomalies more frequently found in AML-M5 are also dealt with as compared to this patient's. The case reported here seems to correspond to subleukaemic acute "monophagocytic" leukaemia, with a biologic phenotype close to that of malignant histiocytosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Leukemia
/
Leukemia, Myeloid
Limits:
Aged
/
Aged80
/
Female
/
Humans
Language:
Es
Journal:
Sangre (Barc)
Year:
1991
Type:
Article