The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

Mocanu, Maria-Magdalena; Nissen, Astrid; Eckermann, Katrin; Khlistunova, Inna; Biernat, Jacek; Drexler, Dagmar; Petrova, Olga; Schönig, Kai; Bujard, Hermann; Mandelkow, Eckhard; Zhou, Lepu; Rune, Gabriele; Mandelkow, Eva-Maria

Mocanu, Maria-Magdalena; Nissen, Astrid; Eckermann, Katrin; Khlistunova, Inna; Biernat, Jacek; Drexler, Dagmar; Petrova, Olga; Schönig, Kai; Bujard, Hermann; Mandelkow, Eckhard; Zhou, Lepu; Rune, Gabriele; Mandelkow, Eva-Maria.

Affiliation

Mocanu MM; Max Planck Unit for Structural Molecular Biology, 22607 Hamburg, Germany.

J Neurosci ; 28(3): 737-48, 2008 Jan 16.

Article in En | MEDLINE | ID: mdl-18199773

Subject(s)

Neurons/pathology; Synapses/pathology; Tauopathies/metabolism; Tauopathies/pathology; tau Proteins/chemistry; Age Factors; Animals; Cell Death/physiology; Detergents/pharmacology; Disease Models, Animal; Gene Expression/physiology; Humans; Mice; Mice, Transgenic; Microscopy, Electron, Transmission/methods; Mutation/physiology; Neurofibrillary Tangles/metabolism; Neurofibrillary Tangles/pathology; Neurons/ultrastructure; Phosphorylation; Protein Structure, Tertiary; Sarcosine/analogs & derivatives; Sarcosine/pharmacology; Silver Staining/methods; Synapses/metabolism; Synapses/ultrastructure; tau Proteins/drug effects; tau Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Tau Proteins / Tauopathies / Neurons Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Neurosci Year: 2008 Type: Article Affiliation country: Germany

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