[Primary mediastinal large B-cell lymphoma:a report of 24 cases with literature review].
Ai Zheng
; 27(2): 187-90, 2008 Feb.
Article
in Zh
| MEDLINE
| ID: mdl-18279619
ABSTRACT
BACKGROUND & OBJECTIVE:
Primary mediastinal large B-cell lymphoma (PMBCL) is an uncommon subtybe of diffuse large B-cell lymphoma (DLBCL). This study was to investigate optimal treatment and prognostic factors of PMBCL by analyzing its clinical features.METHODS:
Clinical records of 24 PMBCL patients, treated in Fujian Provincial Tumor Hospital from 1995 to 2005, were reviewed.RESULTS:
Of the 24 patients, 16 were men and 8 were women, aged from 12 to 81; 20 were at stage I-II, 1 at stage III, and 3 at stage IV; 13 had bulk disease; 10 had superior vena cava syndrome; 14 had contiguous infiltration; 15 had lacate dehydrogenase elevation; 11 received chemoradiotherapy, 10 received chemotherapy alone, and 3 received radiotherapy alone; 10 achieved complete remission (CR) after scheduled treatment, 12 achieved partial remission (PR), 1 had stable disease and 1 had progressive disease. The median survival time was 89 months; the 3-year overall survival rate was 69%. At the end of follow-up, the patients initially achieved CR were all alive. International prognostic index (IPI) did not predict survival in this analysis, while bulk disease predicted poor survival.CONCLUSIONS:
PMBCL has a male dominance in this analysis. Its clinical presentation is critical. Prompt diagnosis is needed. Anthracycline-based chemotherapy with radiotherapy may lead to favorable outcome. The patients with bulk disease have poor survival.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lymphoma, Large B-Cell, Diffuse
/
Mediastinal Neoplasms
Type of study:
Diagnostic_studies
/
Prognostic_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Zh
Journal:
Ai Zheng
Journal subject:
NEOPLASIAS
Year:
2008
Type:
Article