N-methylpyridoxamine: novel canine vitamin B6 urine metabolite.
Bioorg Med Chem Lett
; 18(6): 1845-8, 2008 Mar 15.
Article
in En
| MEDLINE
| ID: mdl-18295484
ABSTRACT
Cation-exchange HPLC analysis of urine from dogs given large daily doses of pyridoxamine revealed an unidentified metabolite hypothesized to be N-methylpyridoxamine. Identity was established by N-methylpyridoxamine synthesis and HPLC comparison to the canine metabolite. Compound synthesis was confirmed by IR, NMR, UV-vis and emission spectroscopy. It seems to have less fluorescent character than other routinely-measured vitamin B(6) metabolites. Upon administration of substantial pyridoxamine doses, N-methylpyridoxamine appears to be a quantifiable canine urine metabolite, although, at either pharmacological or dietary pyridoxamine intakes, its relevance to vitamin B(6) metabolism in other species, including humans, is not yet determined.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pyridoxamine
/
Vitamin B 6
/
Dogs
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2008
Type:
Article
Affiliation country:
United States