Slipping past UGT1A1 and multidrug resistance-associated protein 2 in the liver: effects of steric compression and hydrogen bonding on the hepatobiliary elimination of synthetic bilirubins.

McDonagh, Antony F; Boiadjiev, Stefan E; Lightner, David A

McDonagh, Antony F; Boiadjiev, Stefan E; Lightner, David A.

Affiliation

McDonagh AF; Division of Gastroenterology and The Liver Center, Room S-357, Box 0538, University of California San Francisco, San Francisco, CA 94143-0538, USA. tony.mcdonagh@ucsf.edu

Drug Metab Dispos ; 36(5): 930-6, 2008 May.

Article in En | MEDLINE | ID: mdl-18299337

Subject(s)

ATP-Binding Cassette Transporters/metabolism; Bile/metabolism; Bilirubin/pharmacokinetics; Glucuronosyltransferase/metabolism; Liver/metabolism; ATP-Binding Cassette Transporters/genetics; Animals; Bilirubin/analogs & derivatives; Glucuronosyltransferase/genetics; Hydrogen Bonding; Male; Rats; Rats, Gunn

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bile / Bilirubin / Glucuronosyltransferase / ATP-Binding Cassette Transporters / Liver Type of study: Risk_factors_studies Limits: Animals Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2008 Type: Article Affiliation country: United States

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