Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters.

Ventura, Andrea; Young, Amanda G; Winslow, Monte M; Lintault, Laura; Meissner, Alex; Erkeland, Stefan J; Newman, Jamie; Bronson, Roderick T; Crowley, Denise; Stone, James R; Jaenisch, Rudolf; Sharp, Phillip A; Jacks, Tyler

Ventura, Andrea; Young, Amanda G; Winslow, Monte M; Lintault, Laura; Meissner, Alex; Erkeland, Stefan J; Newman, Jamie; Bronson, Roderick T; Crowley, Denise; Stone, James R; Jaenisch, Rudolf; Sharp, Phillip A; Jacks, Tyler.

Affiliation

Ventura A; Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Cell ; 132(5): 875-86, 2008 Mar 07.

Article in En | MEDLINE | ID: mdl-18329372

Subject(s)

MicroRNAs/genetics; MicroRNAs/metabolism; Multigene Family; Sequence Deletion; 3' Untranslated Regions/metabolism; Animals; Apoptosis Regulatory Proteins/metabolism; B-Lymphocytes/cytology; Bcl-2-Like Protein 11; Cell Survival; Embryonic Stem Cells/metabolism; Fetus/cytology; Genes, Lethal; Heart Septal Defects, Ventricular/genetics; Lung Diseases/genetics; Membrane Proteins/metabolism; Mice; Proto-Oncogene Proteins/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Multigene Family / Sequence Deletion / MicroRNAs Type of study: Prognostic_studies Limits: Animals Language: En Journal: Cell Year: 2008 Type: Article Affiliation country: United States

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