Neurogenesis directed by Sirt1.
Nat Cell Biol
; 10(4): 373-4, 2008 Apr.
Article
in En
| MEDLINE
| ID: mdl-18379594
ABSTRACT
Differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1. These findings link a longevity gene to the activity of neuronal stem cells and their response to stress.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Stem Cells
/
Cell Differentiation
/
Sirtuins
/
Neurons
Limits:
Animals
/
Humans
Language:
En
Journal:
Nat Cell Biol
Year:
2008
Type:
Article
Affiliation country:
United States