Neurogenesis directed by Sirt1.

Libert, Sergiy; Cohen, Dena; Guarente, Leonard

Libert, Sergiy; Cohen, Dena; Guarente, Leonard.

Affiliation

Libert S; Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.

Nat Cell Biol ; 10(4): 373-4, 2008 Apr.

Article in En | MEDLINE | ID: mdl-18379594

ABSTRACT

ABSTRACT

Differentiation of neuronal stem cells into astrocytes or neurons is important in maintaining brain function. Oxidative stress and inflammation are now shown to bias differentiation toward astrocytes by modulating activity of the anti-ageing gene Sirt1. These findings link a longevity gene to the activity of neuronal stem cells and their response to stress.

Subject(s)

Cell Differentiation/physiology; Neurons/physiology; Sirtuins/metabolism; Stem Cells/physiology; Animals; Astrocytes/physiology; Basic Helix-Loop-Helix Transcription Factors/genetics; Basic Helix-Loop-Helix Transcription Factors/metabolism; Brain/cytology; Brain/physiology; Humans; Longevity/genetics; Mice; Oxidation-Reduction; Oxidative Stress; Sirtuin 1; Sirtuins/genetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Cell Differentiation / Sirtuins / Neurons Limits: Animals / Humans Language: En Journal: Nat Cell Biol Year: 2008 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google