Disruption of the Bcr-Abl/Hsp90 protein complex: a possible mechanism to inhibit Bcr-Abl-positive human leukemic blasts by novobiocin.

Wu, L X; Xu, J H; Zhang, K Z; Lin, Q; Huang, X W; Wen, C X; Chen, Y Z

Wu, L X; Xu, J H; Zhang, K Z; Lin, Q; Huang, X W; Wen, C X; Chen, Y Z.

Affiliation

Wu LX; Deparment of Pharmacology, Institute of Clinical Pharmacology, Fujian Medical University, Fuzhou, PR China. wlx-lisa@126.com

Leukemia ; 22(7): 1402-9, 2008 Jul.

Article in En | MEDLINE | ID: mdl-18418407

Subject(s)

Blast Crisis/drug therapy; Fusion Proteins, bcr-abl/metabolism; HSP90 Heat-Shock Proteins/metabolism; Leukemia/drug therapy; Novobiocin/pharmacology; Apoptosis/drug effects; Benzamides; Benzoquinones/pharmacology; Caspase 3/metabolism; Caspase 9/metabolism; Cell Proliferation/drug effects; Cytochromes c/metabolism; Extracellular Signal-Regulated MAP Kinases/metabolism; Fusion Proteins, bcr-abl/analysis; HL-60 Cells; HSP90 Heat-Shock Proteins/antagonists & inhibitors; Humans; Imatinib Mesylate; Immunoprecipitation; K562 Cells; Lactams, Macrocyclic/pharmacology; Leukemia/metabolism; Leukemia/pathology; Piperazines/pharmacology; Proteasome Endopeptidase Complex/physiology; Pyrimidines/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leukemia / Blast Crisis / Novobiocin / Fusion Proteins, bcr-abl / HSP90 Heat-Shock Proteins Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2008 Type: Article

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