Genetic polymorphism of CYP1A2 and the toxicity of leflunomide treatment in rheumatoid arthritis patients.

Bohanec Grabar, Petra; Rozman, Blaz; Tomsic, Matija; Suput, Dasa; Logar, Dusan; Dolzan, Vita

Bohanec Grabar, Petra; Rozman, Blaz; Tomsic, Matija; Suput, Dasa; Logar, Dusan; Dolzan, Vita.

Affiliation

Bohanec Grabar P; Institute of Biochemistry, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. petra.bohanec@mf.uni-lj.si

Eur J Clin Pharmacol ; 64(9): 871-6, 2008 Sep.

Article in En | MEDLINE | ID: mdl-18496682

Subject(s)

Antirheumatic Agents/toxicity; Arthritis, Rheumatoid/drug therapy; Cytochrome P-450 CYP1A2/genetics; Isoxazoles/toxicity; Polymorphism, Genetic; Aged; Diarrhea/chemically induced; Dose-Response Relationship, Drug; Female; Humans; Leflunomide; Male; Middle Aged; Nausea/chemically induced; Pharmacogenetics; Pilot Projects; Pruritus/chemically induced; Vomiting/chemically induced

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polymorphism, Genetic / Arthritis, Rheumatoid / Antirheumatic Agents / Cytochrome P-450 CYP1A2 / Isoxazoles Limits: Aged / Female / Humans / Male / Middle aged Language: En Journal: Eur J Clin Pharmacol Year: 2008 Type: Article Affiliation country: Slovenia

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