Synthesis and evaluation of estrogen agonism of diaryl 4,5-dihydroisoxazoles, 3-hydroxyketones, 3-methoxyketones, and 1,3-diketones: a compound set forming a 4D molecular library.

Pulkkinen, Juha T; Honkakoski, Paavo; Peräkylä, Mikael; Berczi, Istvan; Laatikainen, Reino

Pulkkinen, Juha T; Honkakoski, Paavo; Peräkylä, Mikael; Berczi, Istvan; Laatikainen, Reino.

Affiliation

Pulkkinen JT; Laboratories of Chemistry, Biochemistry, Department of Biosciences, University of Kuopio, PO Box 1627, FIN-70211 Kuopio, Finland. juha.pulkkinen@uku.fi

J Med Chem ; 51(12): 3562-71, 2008 Jun 26.

Article in En | MEDLINE | ID: mdl-18517258

Subject(s)

Estrogen Receptor alpha/agonists; Estrogen Receptor beta/agonists; Isoxazoles/chemical synthesis; Ketones/chemical synthesis; Binding Sites; Cell Line; Estrogen Receptor alpha/genetics; Estrogen Receptor beta/genetics; Humans; Isoxazoles/chemistry; Isoxazoles/pharmacology; Ketones/chemistry; Ketones/pharmacology; Ligands; Models, Molecular; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Estrogen Receptor alpha / Estrogen Receptor beta / Isoxazoles / Ketones Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2008 Type: Article Affiliation country: Finland

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