Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis.

Joosten, Leo A B; Heinhuis, Bas; Abdollahi-Roodsaz, Shahla; Ferwerda, Gerben; Lebourhis, Lionel; Philpott, Dana J; Nahori, Marie-Anne; Popa, Calin; Morre, Servaas A; van der Meer, Jos W M; Girardin, Stephen E; Netea, Mihai G; van den Berg, Wim B

Joosten, Leo A B; Heinhuis, Bas; Abdollahi-Roodsaz, Shahla; Ferwerda, Gerben; Lebourhis, Lionel; Philpott, Dana J; Nahori, Marie-Anne; Popa, Calin; Morre, Servaas A; van der Meer, Jos W M; Girardin, Stephen E; Netea, Mihai G; van den Berg, Wim B.

Affiliation

Joosten LA; Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. l.joosten@aig.umcn.nl

Proc Natl Acad Sci U S A ; 105(26): 9017-22, 2008 Jul 01.

Article in En | MEDLINE | ID: mdl-18574154

Subject(s)

Arthritis, Rheumatoid/metabolism; Nod1 Signaling Adaptor Protein/metabolism; Nod2 Signaling Adaptor Protein/metabolism; Animals; Arthritis, Rheumatoid/pathology; Cell Line; Cell Wall/metabolism; Gene Expression Regulation; Humans; Interleukin-1beta/biosynthesis; Leukocytes, Mononuclear/metabolism; Male; Mice; Mice, Inbred C57BL; Mutation/genetics; Nod1 Signaling Adaptor Protein/deficiency; Nod1 Signaling Adaptor Protein/genetics; Nod2 Signaling Adaptor Protein/deficiency; Nod2 Signaling Adaptor Protein/genetics; Streptococcus; Synovial Membrane/metabolism; Synovial Membrane/pathology; Tumor Necrosis Factor-alpha/biosynthesis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Nod1 Signaling Adaptor Protein / Nod2 Signaling Adaptor Protein Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Proc Natl Acad Sci U S A Year: 2008 Type: Article Affiliation country: Netherlands

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