Design and optimization of potent, selective antagonists of Oxytocin.
Bioorg Med Chem Lett
; 18(15): 4278-81, 2008 Aug 01.
Article
in En
| MEDLINE
| ID: mdl-18639455
ABSTRACT
A novel series of Oxytocin antagonists are described. This series was identified through pharmacophoric overlap of in-house and literature antagonists. Subsequent optimization led to a series of potent, selective antagonists. Several analogues displayed oral bioavailability in vivo in the rat.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxytocics
/
Triazoles
/
Oxytocin
Limits:
Animals
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2008
Type:
Article
Affiliation country:
United kingdom