Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil.

Ganzinelli, Monica; Carrassa, Laura; Crippa, Francesca; Tavecchio, Michele; Broggini, Massimo; Damia, Giovanna

Ganzinelli, Monica; Carrassa, Laura; Crippa, Francesca; Tavecchio, Michele; Broggini, Massimo; Damia, Giovanna.

Affiliation

Ganzinelli M; Laboratory of Molecular Pharmacology, Department of Oncology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.

Clin Cancer Res ; 14(16): 5131-41, 2008 Aug 15.

Article in En | MEDLINE | ID: mdl-18698031

Subject(s)

Antineoplastic Agents/therapeutic use; Cell Cycle/physiology; Cell Line, Tumor/physiology; Fluorouracil/therapeutic use; Neoplasms, Experimental/drug therapy; Protein Kinases/metabolism; Animals; Blotting, Western; Boronic Acids; Bortezomib; Checkpoint Kinase 1; Down-Regulation; Doxorubicin/pharmacology; Etoposide/pharmacology; Female; Fluorescent Antibody Technique; Genes, p53; Humans; Immunohistochemistry; Mice; Mice, Nude; Neoplasms, Experimental/genetics; Neoplasms, Experimental/metabolism; Paclitaxel/pharmacology; Pyrazines; RNA, Small Interfering; Transfection; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Kinases / Cell Cycle / Cell Line, Tumor / Fluorouracil / Neoplasms, Experimental / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Clin Cancer Res Journal subject: NEOPLASIAS Year: 2008 Type: Article Affiliation country: Italy

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