Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors.

Pinard, Emmanuel; Alberati, Daniela; Borroni, Edilio; Fischer, Holger; Hainzl, Dominik; Jolidon, Synèse; Moreau, Jean-Luc; Narquizian, Robert; Nettekoven, Matthias; Norcross, Roger D; Stalder, Henri; Thomas, Andrew W

Pinard, Emmanuel; Alberati, Daniela; Borroni, Edilio; Fischer, Holger; Hainzl, Dominik; Jolidon, Synèse; Moreau, Jean-Luc; Narquizian, Robert; Nettekoven, Matthias; Norcross, Roger D; Stalder, Henri; Thomas, Andrew W.

Affiliation

Pinard E; F. Hoffmann-La Roche Ltd, Pharmaceutical Research Basel, Discovery Chemistry, CH-4070 Basel, Switzerland. emmanuel.pinard@roche.com

Bioorg Med Chem Lett ; 18(18): 5134-9, 2008 Sep 15.

Article in En | MEDLINE | ID: mdl-18752953

Subject(s)

Benzoates/chemistry; Benzoates/pharmacology; Glycine Plasma Membrane Transport Proteins/antagonists & inhibitors; Piperazines/chemistry; Piperazines/pharmacology; Administration, Oral; Brain/drug effects; Combinatorial Chemistry Techniques; Drug Design; Molecular Structure; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Benzoates / Glycine Plasma Membrane Transport Proteins Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Type: Article Affiliation country: Switzerland

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