Multiple levels of selection responsive to immunoglobulin light chain and heavy chain structures impede the development of Dmu-expressing B cells.

Guloglu, F Betul; Smith, Brendan P; Roman, Christopher A J

Guloglu, F Betul; Smith, Brendan P; Roman, Christopher A J.

Affiliation

Guloglu FB; The School of Graduate Studies, Program in Molecular and Cellular Biology, State University of New York-Downstate Medical Center at Brooklyn, Brooklyn, NY 11203, USA.

J Immunol ; 181(6): 4098-106, 2008 Sep 15.

Article in En | MEDLINE | ID: mdl-18768866

Subject(s)

B-Lymphocyte Subsets/immunology; Cell Differentiation/immunology; Gene Rearrangement, B-Lymphocyte, Light Chain; Immunoglobulin Heavy Chains/physiology; Immunoglobulin Light Chains, Surrogate/physiology; Immunoglobulin kappa-Chains/physiology; Immunoglobulin lambda-Chains/physiology; Stem Cells/immunology; Alleles; Animals; B-Lymphocyte Subsets/metabolism; Cell Differentiation/genetics; Cell Line; Cell Line, Transformed; Cells, Cultured; Humans; Immunoglobulin Heavy Chains/biosynthesis; Immunoglobulin Heavy Chains/genetics; Immunoglobulin Light Chains, Surrogate/biosynthesis; Immunoglobulin Light Chains, Surrogate/genetics; Immunoglobulin kappa-Chains/biosynthesis; Immunoglobulin kappa-Chains/genetics; Immunoglobulin lambda-Chains/biosynthesis; Immunoglobulin lambda-Chains/genetics; Mice; Mice, Knockout; Mutagenesis; Receptors, Antigen, B-Cell/biosynthesis; Receptors, Antigen, B-Cell/genetics; Receptors, Antigen, B-Cell/physiology; Stem Cells/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Stem Cells / Gene Rearrangement, B-Lymphocyte, Light Chain / Cell Differentiation / B-Lymphocyte Subsets / Immunoglobulin Heavy Chains / Immunoglobulin kappa-Chains / Immunoglobulin lambda-Chains / Immunoglobulin Light Chains, Surrogate Limits: Animals / Humans Language: En Journal: J Immunol Year: 2008 Type: Article Affiliation country: United States

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