Doxorubicin increases the susceptibility of brain mitochondria to Ca(2+)-induced permeability transition and oxidative damage.

Cardoso, Susana; Santos, Renato X; Carvalho, Cristina; Correia, Sónia; Pereira, Gonçalo C; Pereira, Susana S; Oliveira, Paulo J; Santos, Maria S; Proença, Teresa; Moreira, Paula I

Cardoso, Susana; Santos, Renato X; Carvalho, Cristina; Correia, Sónia; Pereira, Gonçalo C; Pereira, Susana S; Oliveira, Paulo J; Santos, Maria S; Proença, Teresa; Moreira, Paula I.

Affiliation

Cardoso S; Department of Zoology, Faculty of Sciences and Technology, University of Coimbra, 3000-354 Coimbra, Portugal.

Free Radic Biol Med ; 45(10): 1395-402, 2008 Nov 15.

Article in En | MEDLINE | ID: mdl-18775776

Subject(s)

Brain/cytology; Calcium/pharmacology; Doxorubicin/pharmacology; Mitochondria/drug effects; Mitochondria/metabolism; Mitochondrial Membrane Transport Proteins/metabolism; Oxidative Stress/drug effects; Animals; Antioxidants/metabolism; Antioxidants/pharmacology; Glutathione/antagonists & inhibitors; Glutathione/metabolism; Male; Mitochondrial Permeability Transition Pore; Oxidation-Reduction/drug effects; Rats; Rats, Wistar; Vitamin E/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Doxorubicin / Calcium / Oxidative Stress / Mitochondrial Membrane Transport Proteins / Mitochondria Limits: Animals Language: En Journal: Free Radic Biol Med Journal subject: BIOQUIMICA / MEDICINA Year: 2008 Type: Article Affiliation country: Portugal

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