IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17.

Hashizume, M; Hayakawa, N; Mihara, M

Hashizume, M; Hayakawa, N; Mihara, M.

Affiliation

Hashizume M; Product Research Department, Chugai Pharmaceutical Co. Ltd, Komakado, Gotemba, Shizuoka, Japan.

Rheumatology (Oxford) ; 47(11): 1635-40, 2008 Nov.

Article in En | MEDLINE | ID: mdl-18786965

Subject(s)

Arthritis, Rheumatoid/metabolism; Interleukin-17/pharmacology; Interleukin-6/metabolism; RANK Ligand/metabolism; Synovial Membrane/metabolism; Tumor Necrosis Factor-alpha/pharmacology; Antibodies, Monoclonal/pharmacology; Antibodies, Monoclonal, Humanized; Blotting, Western/methods; Cell Proliferation/drug effects; Cells, Cultured; Fibroblasts; Flavonoids/pharmacology; Humans; Immunohistochemistry; Interleukin-1beta/pharmacology; Interleukin-6/pharmacology; Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors; Mitogen-Activated Protein Kinase Kinases/metabolism; Phosphorylation/drug effects; RANK Ligand/analysis; RANK Ligand/genetics; RNA, Messenger/analysis; Receptor Activator of Nuclear Factor-kappa B/metabolism; Receptors, Interleukin-6/antagonists & inhibitors; Receptors, Interleukin-6/metabolism; Recombinant Proteins/pharmacology; Reverse Transcriptase Polymerase Chain Reaction/methods; STAT3 Transcription Factor/metabolism; Sesquiterpenes/pharmacology; Signal Transduction/physiology; Stimulation, Chemical; Synovial Membrane/drug effects

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Rheumatoid / Synovial Membrane / Interleukin-6 / Tumor Necrosis Factor-alpha / Interleukin-17 / RANK Ligand Limits: Humans Language: En Journal: Rheumatology (Oxford) Journal subject: REUMATOLOGIA Year: 2008 Type: Article Affiliation country: Japan

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